Synthesis and Cytotoxic Activity of Novel Betulin Derivatives Containing Hydrazide-Hydrazone Moieties
نویسندگان
چکیده
A series of novel betulin derivatives containing hydrazide-hydrazone moieties were synthesized. All compounds evaluated for their cytotoxicity against four human carcinoma cell lines (HepG2, A549, MCF-7 and HCT-116) a normal gastric epithelial line (GES-1). Among them, compound 6i was the most potent HepG2 lines, with IC 50 values 9.27 8.87 μM, respectively. The results suggest that incorporation side chain at C-28 position is beneficial to display significant cytotoxicity. Compound may be used as promising skeleton antitumor agents improved efficacy.
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ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2021
ISSN: ['1555-9475', '1934-578X']
DOI: https://doi.org/10.1177/1934578x211055345